Hydrochloric Acid → HCID 21538576, Verbindung

HRID 1076915

Reaktionsgleichung

Reaktionsgleichung von HRID 1076915
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[O:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)OC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[O:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

Komponenten

6

Edukt 4

HCID 313Hydrochloric Acid2×HCID 7107XantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538574HCID 21538574, Verbindung

Produkt 1

HCID 21538576HCID 21538576, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2,7-Bis(4-phthalimidobutyryl)xanthene, prepared from 4-phthalimidobutyryl chloride and xanthene by the method of S. S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with 700 ml. of hot glacial acetic acid after which 200 ml. of concentrated hydrochloric acid is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

Aufarbeitung

  1. addition9, 945 (1966), is treated with 700 ml
  2. temperatureThe mixture is heated
  3. stirringis stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

Quellen und Nachweise

ORD-Eintrag
ord-48f747910c064377ac980362554069e3
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03957989

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