Acetone → 2,2,6,6-Tetramethyl-4-piperidone

HRID 1076991

Reaktionsgleichung

Reaktionsgleichung von HRID 1076991
[NH3:1].[Cl-].[NH4+].[CH3:4][C:5](=[O:11])[CH2:6][C:7]([CH3:10])(O)[CH3:8].[CH3:12][C:13]([CH3:15])=O>CO>[CH3:8][C:7]1([CH3:10])[CH2:6][C:5](=[O:11])[CH2:4][C:13]([CH3:15])([CH3:12])[NH:1]1

Komponenten

6

Edukt 4

HCID 180Acetone2×HCID 222AmmoniaHCID 25517Ammonium ChlorideHCID 31256Diacetone Alcohol

Produkt 1

HCID 132202,2,6,6-Tetramethyl-4-piperidoneAusbeute 42,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

40 g of ammonia gas is introduced in the course of about 4 hours at 13°-15°C into a mixture consisting of 126 g of acetone, 22.5 g of methanol and 4.7 g of ammonium chloride. The reaction mixture is subsequently stirred for a further 30 minutes at the same temperature. An addition is then made to the reaction mixture of 220 g of diacetone alcohol and 110 g of acetone; the whole is heated within 1 hour to 55°C and held at this temperature for 12 hours. Processing by fractional distillation yields 125 g of 2,2,6,6-tetramethyl-4-oxopiperidine.

Aufarbeitung

  1. additionAn addition
  2. temperaturethe whole is heated within 1 hour to 55°C
  3. waitheld at this temperature for 12 hours
  4. distillationProcessing by fractional distillation

Quellen und Nachweise

ORD-Eintrag
ord-cf1a88b58c114088b8cc7444358aa2c9
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03959295

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