Formaldehyde → HCID 21535614, Verbindung

HRID 1076997

Reaktionsgleichung

Reaktionsgleichung von HRID 1076997
[C:1]([N:5]([CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3].[CH2:18]=O.[CH:20]1[CH:21]=[C:22]2[C:27]3=[C:28]([C:30]([NH:32][C:33](=[O:34])[C:26]3=[CH:25][CH:24]=[CH:23]2)=[O:31])[CH:29]=1>CN(C)C=O>[O:31]=[C:30]1[C:28]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][C:26]=3[C:33](=[O:34])[N:32]1[CH2:18][N:15]1[CH2:14][CH2:13][CH:12]([N:5]([C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)[C:1](=[O:4])[CH2:2][CH3:3])[CH2:17][CH2:16]1)[CH:21]=[CH:20][CH:29]=2

Komponenten

5

Edukt 3

HCID 712FormaldehydeHCID 66491NaphthalimideHCID 2593814-(N-Propionylaniline)piperidine

Produkt 1

HCID 21535614HCID 21535614, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

An equimolar mixture of 4-(N-propionylanilino)piperidine, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield N-[1-[(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)methyl]-4-piperidinyl]-N-phenylpropanamide.

Aufarbeitung

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-fd5645c8b7274977960199a92827b267
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03959286

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