Benzene → HCID 12906828, Verbindung

HRID 1077028

Reaktionsgleichung

Reaktionsgleichung von HRID 1077028
C1C=CC=CC=1.[CH3:7][C:8]1([CH3:14])[NH:12][CH2:11][CH:10]([CH3:13])[O:9]1.C(N(CC)CC)C.[Br:22][CH:23]([CH2:27][Br:28])[C:24](Cl)=[O:25]>O>[CH3:7][C:8]1([CH3:14])[N:12]([C:24](=[O:25])[CH:23]([Br:22])[CH2:27][Br:28])[CH2:11][CH:10]([CH3:13])[O:9]1

Komponenten

6

Edukt 4

HCID 241Benzene2×HCID 8471TriethylamineHCID 867902,3-Dibromopropanoyl chlorideHCID 95486Oxazolidine, 2,2,5-trimethyl-

Produkt 1

HCID 12906828HCID 12906828, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Fourteen milliliters of a benzene solution containing 3.5 g. of 2,2,5-trimethyl oxazolidine was added to 25 ml. of benzene and 3.5 g. of triethylamine. Seven and one-half grams of 2,3-dibromopropionyl chloride was added dropwise with stirring and cooling in an ice bath. When reaction was complete, the mixture was poured into water and the benzene layer separated, dried over anhydrous magnesium sulfate and the solvent stripped under vacuum. The yield was 5.7 g. of an oil, nD30 = 1.5060.

Aufarbeitung

  1. temperaturecooling in an ice bath
  2. customWhen reaction
  3. customthe benzene layer separated
  4. dry with materialdried over anhydrous magnesium sulfate

Quellen und Nachweise

ORD-Eintrag
ord-901566a40ea94522a7749acc58167ccf
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03959304

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