Water → 3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

HRID 1077820Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077820
[H-].[Na+].[CH2:3]([OH:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1.O>C1COCC1>[CH2:3]([O:9][C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Komponenten

6

Edukt 4

HCID 962WaterHCID 81031-HexanolHCID 24758Sodium hydrideHCID 190752683-(3-Chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine

Produkt 1

HCID 190755123-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Sodium hydride (0.72 g, 15 mmol) was dissolved in dry THF (20 ml) and 1-hexanol (1.53 g, 15 mmol) and a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine (1.06 g, 5 mmol) in dry THF (15 ml) was added. The reaction mixture was stirred for 2 h. After addition of water the mixture was extracted with ether, and the ether phase was dried and evaporated. The residue consisted of the crude title compound, which was used without further purification.

Aufarbeitung

  1. extractionwas extracted with ether
  2. dry with materialthe ether phase was dried
  3. customevaporated
  4. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-d98b0f009cd24cd780fa86b96ce96c17
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05545638

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