Methanol → HCID 70045154, Verbindung

HRID 1077881Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077881
C([O:3][C:4](=[O:27])[C:5]([C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:26])[CH2:13][CH2:14][C:15](=[O:25])[N:16]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:17])=[O:6])C.C(=O)([O-])[O-].[K+].[K+].CO>O>[OH2:3].[CH2:18]([N:16]([CH3:17])[C:15]([CH2:14][CH2:13][C:12]([N:8]1[CH2:9][CH2:10][CH2:11][C@H:7]1[C:5](=[O:6])[C:4]([OH:27])=[O:3])=[O:26])=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

5

Edukt 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 156609222-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl ester

Produkt 1

HCID 70045154HCID 70045154, VerbindungAusbeute 150,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

A mixture of 2-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl) propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl ester (626 mg), potassium carbonate (277 mg), methanol (7 ml) and water (4 ml) was stirred for 1 hr. at room temperature. Water was added to the reaction solution. The mixture was extracted with EtOAc. The extract was washed, dried and evaporated to give the title compound (458 mg) having the following physical data:

Aufarbeitung

  1. customat room temperature
  2. extractionThe mixture was extracted with EtOAc
  3. washThe extract was washed
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e3753def275c4db889212147917129d4
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05545657

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