N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea → 1-(2,4-difluorophenyl)-2(1H,3H)-imidazolone

HRID 1077893Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077893
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])=[O:8])C>CO.O.Cl>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[N:9]1[CH:4]=[CH:5][NH:6][C:7]1=[O:8]

Komponenten

5

Edukt 1

HCID 19065111N-(2,2-diethoxyethyl)-N'-(2,4-difluorophenyl)urea

Produkt 1

HCID 190650921-(2,4-difluorophenyl)-2(1H,3H)-imidazoloneAusbeute 89,4 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

This urea compound (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water, 300 ml of 0.48M hydrochloric acid was added thereto and the mixture was stirred at room temperature for three days. The reaction solution was concentrated under reduced pressure and the crystals separated out were washed with a mixture of water and methanol (5:1) to give 22.8 g of 1-(2,4-difluorophenyl)-2-(1H,3H)-imidazolone as a colorless powder.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe crystals separated out
  4. washwere washed with a mixture of water and methanol (5:1)

Quellen und Nachweise

ORD-Eintrag
ord-fd1afeae18914c18ad6669ea4a3ee72f
Quelldatensatz
uspto-grants-1996_08
Patentnummer
US05545652

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