1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 10779

Reaktionsgleichung

Reaktionsgleichung von HRID 10779
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

Produkt 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-oneAusbeute 63,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-acetyl-4-(4-nitrophenyl)piperazine (1.8 g, 7.2 mmol) (from Step A above) and 10% palladium-on-charcoal in ethanol (50 mL) was hydrogenated at room temperature and atmospheric pressure overnight. The catalyst was filtered off and the filter cake washed thoroughly with ethanol. The mixture was evaporated under reduced pressure to give 1-acetyl-4-(4-amino-phenyl)piperazine (1.0 g, 63%) as an off-white solid.

Aufarbeitung

  1. customwas hydrogenated at room temperature
  2. customatmospheric pressure overnight
  3. filtrationThe catalyst was filtered off
  4. washthe filter cake washed thoroughly with ethanol
  5. customThe mixture was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-c84ff7750f7042e88d7b296e98f6f5f4
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094896B2

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