Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone

HRID 10789

Reaktionsgleichung

Reaktionsgleichung von HRID 10789
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 5185963',5'-Difluoroacetophenone

Produkt 1

HCID 27783312-Bromo-1-(3,5-difluorophenyl)ethanoneAusbeute 64,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).

Aufarbeitung

  1. concentrationthe mixture was concentrated in vacuo
  2. customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant

Quellen und Nachweise

ORD-Eintrag
ord-b766bbeecace419eaa52b615ff7cd9e8
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094896B2

Verknüpfte Notizen

Wird geladen…