Bromine → 2-Bromo-1-(3,5-difluorophenyl)ethanone
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[C:6]([F:8])[CH:7]=1.[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=1)=[O:11]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 3′,5′-difluoroacetophenone (3 g, 19.2 mmol) (Lancaster Synthesis) in dioxane (30 mL) was added dropwise a solution of bromine (3.67 g, 23 mmol) in dioxane (75 mL). After stirring for 10 minutes, the mixture was concentrated in vacuo and the residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant, to provide 2-bromo-1-(3,5-difluorophenyl)ethanone as a colorless oil (2.9 g, 64% yield).
Aufarbeitung
- concentrationthe mixture was concentrated in vacuo
- customthe residue was purified by flash chromatography, with 10:2 hexanes/dichloromethane as an eluant
Quellen und Nachweise
- ORD-Eintrag
- ord-b766bbeecace419eaa52b615ff7cd9e8
- Quelldatensatz
- uspto-grants-2006_08
- Patentnummer
- US07094896B2
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