Acetyl chloride → N-(4-(1-Piperidinyl)phenyl)acetamide

HRID 1079394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1079394
Cl.Cl.[NH2:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:6][CH:5]=1.C(N(CC)CC)C.[C:23](Cl)(=[O:25])[CH3:24]>O>[C:23]([NH:3][C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)=[CH:8][CH:9]=1)(=[O:25])[CH3:24]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 233669404-(Piperidin-1-yl)aniline dihydrochloride

Produkt 1

HCID 732499N-(4-(1-Piperidinyl)phenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of N-(4-aminophenyl)piperidine dihydrochloride (2.49 g) and triethylamine (5.6 g) in dichloroform (30 ml) was ice-cooled and to this was added dropwise acetyl chloride (1.42 ml). After stirred at room temperature for 30 minutes, water (10 ml) was added to the mixture and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off and then the residue was recrystallized from ethyl ether to obtain N(4-acetylaminophenyl)piperidine (2 g) as colorless crystals, m.p. 150°-152° C.

Aufarbeitung

  1. temperaturecooled
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. distillationThe solvent was distilled off
  4. customthe residue was recrystallized from ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-45b0e8bf45724a65aa6aa2fdba130a55
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05580883

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