Hydrochloric Acid → 1-(3-Aminophenyl)piperidine dihydrochloride

HRID 1079398Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1079398
[N+:1]([C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1)([O-])=O.[ClH:16]>CO.[Pd]>[ClH:16].[ClH:16].[NH2:1][C:4]1[CH:5]=[C:6]([N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 147652751-(3-Nitrophenyl)piperidine

Produkt 1

HCID 233669441-(3-Aminophenyl)piperidine dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of N-(3-nitrophenyl)piperidine (12 g) in methanol (50 ml) was added conc. hydrochloric acid (12 ml) and, by using 10% palladium/carbon as a catalyst, catalytic reduction was conducted at normal temperature under normal pressure. After completion of the reaction, the catalyst was removed and the solvent was distilled off. Ethyl ether was added to the residue and the mixture was filtered off to obtain N-(3-aminophenyl)piperidine dihydrochloride (13.2 g) as a colorless solid.

Aufarbeitung

  1. customAfter completion of the reaction
  2. customthe catalyst was removed
  3. distillationthe solvent was distilled off
  4. additionEthyl ether was added to the residue
  5. filtrationthe mixture was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-d3a17d2545f9416e8816ac7874cbd5ba
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05580883

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