Ammonium Chloride → beta(R)-benzyloxy-alpha(RS)-phenyl-1,4-dioxaspiro[4,5]decane-2(R)-ethanol

Temperatur

5 °C

A solution of 4.30 g (0.015 mmol) of α(S)-benzyloxy-1,4-dioxaspiro[4,5]decane-2(R)-acetaldehyde in 50 ml of anhydrous diethyl ether was cooled to -8° C. and 15 ml of a 2M solution of phenylmagnesium chloride in tetrahydrofuran were added dropwise over a period of 1 hour. The mixture was stirred at-5° C. for 2 hours then allowed to warm to room temperature and poured into 50 ml of 10% ammonium chloride solution. The mixture was extracted twice with 100 ml of ethyl acetate each time. The ethyl acetate extracts were dried over anhydrous magnesium sulphate and evaporated. The residue was subjected to flash chromatography on silica gel using 5% methanol in dichloromethane for the elution. There were obtained 2.47 g of β(R)-benzyloxy-α(RS)-phenyl-1,4-dioxaspiro[4,5]decane-2(R)-ethanol in the form of a colourless gum; MS (C.I.): m/e 369 [M+H]+.

1. temperatureto warm to room temperature
2. extractionThe mixture was extracted twice with 100 ml of ethyl acetate each time
3. dry with materialThe ethyl acetate extracts were dried over anhydrous magnesium sulphate
4. customevaporated
5. washThe residue was subjected to flash chromatography on silica gel using 5% methanol in dichloromethane for the elution

ORD-Eintrag

ord-9ad13f9249e54c3a9ce6c314edca06ed

Quelldatensatz

uspto-grants-1996_12

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05580999