Oxalyl chloride → 2,3,4,5-Tetrafluoro-6-methylbenzoyl chloride

HRID 1081391

Reaktionsgleichung

Reaktionsgleichung von HRID 1081391
[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:7]([CH3:14])[C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:18])=O>CN(C=O)C.ClCCl>[F:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[C:7]([CH3:14])[C:3]=1[C:4]([Cl:18])=[O:5]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 129439972,3,4,5-Tetrafluoro-6-methylbenzoic acid

Produkt 1

HCID 146512562,3,4,5-Tetrafluoro-6-methylbenzoyl chlorideAusbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 8.2 g (39.4 mmol) of 2,3,4,5-tetrafluoro-6-methylbenzoic acid, 6.0 g (47.2 mmol) of oxalyl chloride, and 100 mL of dichloromethane was treated with three drops of DMF. The solution was stirred for 3 hours, then concentrated to give 8.8 g of the title compound as a yellow liquid. The product was used as is in the next step.

Aufarbeitung

  1. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5d05344005574118b5d716446c84e88d
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05585491

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