Tetramethyl pyrazine-2,3,5,6-tetracarboxylate → 2,3,5,6-Tetramethoxycarbonylpiperazine

HRID 1081534Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1081534
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[C:8]([C:15]([O:17][CH3:18])=[O:16])=[N:7][C:6]=1[C:19]([O:21][CH3:22])=[O:20])=[O:4]>C(O)C.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:6]([C:19]([O:21][CH3:22])=[O:20])[NH:7][CH:8]([C:15]([O:17][CH3:18])=[O:16])[CH:9]([C:11]([O:13][CH3:14])=[O:12])[NH:10]1)=[O:4]

Komponenten

4

Edukt 1

HCID 291621Tetramethyl pyrazine-2,3,5,6-tetracarboxylate

Produkt 1

HCID 233626442,3,5,6-Tetramethoxycarbonylpiperazine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of tetrakis-methoxycarbonylpyrazine (5.3 g, 16.9 mmol) (prepared in accordance with J. Org. Chem. 37 (19), p 2963 (1972)) in 800 ml of dry ethanol, was hydrogenated at 50 bar in the presence of 10 g 5% palladium on charcoal at 80° C. for 16 hours. After cooling, the solution was filtered and evaporated to give slightly yellow crystals:

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe solution was filtered
  3. customevaporated
  4. customto give slightly yellow crystals

Quellen und Nachweise

ORD-Eintrag
ord-f9da53005e834965966f61e6c82a668b
Quelldatensatz
uspto-grants-1996_12
Patentnummer
US05587144

Notizen zur Reaktion

Wird geladen…