Cyclopentanone → 1-(Methylamino)cyclopentane-1-carbonitrile
Reaktionsgleichung
[C-:1]#[N:2].[K+].[C:4]1(=O)[CH2:8][CH2:7][CH2:6][CH2:5]1.Cl.[CH3:11][NH2:12]>O>[CH3:1][NH:2][C:4]1([C:11]#[N:12])[CH2:8][CH2:7][CH2:6][CH2:5]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of 6.5 of potassium cyanide in 13 ml of water was added at 15°-20° C. to a solution of 8.5 g of cyclopentanone and 7 g of methylamine hydrochloride in 7.5 ml of water and returned to room temperature; the mixture was stirred for 18 hours and extracted with methylene chloride. The organic phase was washed with aqueous sodium chloride, dried, and evaporated to dryness, and the residue was distilled to obtain 4.1 g of the expected product with a boiling point of 60° C.±0.3° C. at 7 mm of Hg.
Aufarbeitung
- customreturned to room temperature
- extractionextracted with methylene chloride
- washThe organic phase was washed with aqueous sodium chloride
- customdried
- customevaporated to dryness
- distillationthe residue was distilled
Quellen und Nachweise
- ORD-Eintrag
- ord-254ea29eb8be400f94a87657c6f1d3e6
- Quelldatensatz
- uspto-grants-1996_12
- Patentnummer
- US05589497
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