Isophthalaldehyde → 3-(2-(6-Phenylpyridin-2-yl)ethenyl)benzaldehyde

HRID 1084425

Reaktionsgleichung

[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1.[CH:14](=O)[C:15]1[CH:22]=[CH:21][CH:20]=[C:17]([CH:18]=[O:19])[CH:16]=1>[Cl-].[Zn+2].[Cl-]>[C:8]1([C:4]2[N:3]=[C:2]([CH:1]=[CH:14][C:15]3[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=3)[CH:18]=[O:19])[CH:7]=[CH:6][CH:5]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

Reaktionsbedingungen

Temperatur: 160 °C

Versuchsvorschrift

A mixture of 2-methyl-6-phenylpyridine (525 mg) (step 2), isophthalaldehyde (630 mg) and dry zinc chloride (40 mg) was heated at 160° C. under N2 for 3 hours. The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer was washed with H2O (10 cc), brine and solvent as removed in vacuo. The residue was purified by chromatography to afford the title compound.

Aufarbeitung

customThe resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer
washwas washed with H2O (10 cc), brine and solvent
customas removed in vacuo
customThe residue was purified by chromatography

Quellen und Nachweise

ORD-Eintrag: ord-f283381da93346dab8a20399803753e3
Quelldatensatz: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05004743

Verknüpfte Notizen

Wird geladen…