Hydrochloric Acid → HCID 20062840, Verbindung

HRID 1084958

Reaktionsgleichung

Reaktionsgleichung von HRID 1084958
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1.[CH2:17]([NH2:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[ClH:25]>O>[ClH:25].[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][O:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:24][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:11][CH:12]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 7504BenzylamineHCID 197980301-[2-[(5-Bromopentyl)oxy]ethyl]-4-fluorobenzene

Produkt 1

HCID 20062840HCID 20062840, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

1-[2-[(5-Bromopentyl)oxy]ethyl]-4-fluorobenzene (7.95 g) was added dropwise over 10 min to benzylamine (24 ml) at 125° under nitrogen. The reaction mixture was stirred for 3.5 h at 120° and the hot reaction mixture was poured into 2N aqueous hydrochloric acid (170 ml) and water (220 ml). After stirring for 15 min the precipitate was collected by filtration to give the title compound as a white solid (7.41 g) m.p. 112°.

Aufarbeitung

  1. stirringAfter stirring for 15 min the precipitate
  2. filtrationwas collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-739e1043029d4258b88614d783964259
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05006556

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