Ethanol → HCID 86744734, Verbindung

HRID 1085464Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085464
[NH:1]([C:3]1[N:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH:10]2[CH2:12][CH2:11]2)[N:4]=1)[NH2:2].C[CH2:14][C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O.[CH2:23](O)C>>[CH3:9][C:7]1[CH:6]=[C:5]([CH:10]2[CH2:11][CH2:12]2)[N:4]=[C:3]([NH:1][N:2]=[C:15]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])[CH3:14])[N:8]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 71481-Phenyl-1-propanoneHCID 20060099HCID 20060099, Verbindung

Produkt 1

HCID 86744734HCID 86744734, Verbindung

Versuchsvorschrift

3.3 g of 2-hydrazino-4-methyl-6-cyclopropylpyrimidine and 2.7 g of 2-methylacetophenone are heated to boiling in 40 ml of ethanol and boiled under reflux for 20 hours with stirring. The reaction solution is then cooled and the solvent is evaporated off in vacuo. For purification, the oily residue is chromatographed using hexane/ethyl acetate (2:1) over a column of silica gel.

Aufarbeitung

  1. temperatureunder reflux for 20 hours
  2. temperatureThe reaction solution is then cooled
  3. customthe solvent is evaporated off in vacuo
  4. customFor purification
  5. customthe oily residue is chromatographed

Quellen und Nachweise

ORD-Eintrag
ord-47e23cb0af584577b7e81ede76200279
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05010082

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