Methyl iodide → 3-(N,N,N-trimethylammonio)-1-(3,4,5-trimethoxyphenyl)propan-1-one iodide

HRID 1085627

Reaktionsgleichung

Reaktionsgleichung von HRID 1085627
[CH3:1][N:2]([CH2:4][CH2:5][C:6]([C:8]1[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=1)=[O:7])[CH3:3].[CH3:20][I:21]>CCOCC>[I-:21].[CH3:1][N+:2]([CH2:4][CH2:5][C:6]([C:8]1[CH:9]=[C:10]([O:18][CH3:19])[C:11]([O:16][CH3:17])=[C:12]([O:14][CH3:15])[CH:13]=1)=[O:7])([CH3:20])[CH3:3]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 4123063-(Dimethylamino)-1-(3,4,5-trimethoxyphenyl)propan-1-one

Produkt 1

HCID 104092223-(N,N,N-trimethylammonio)-1-(3,4,5-trimethoxyphenyl)propan-1-one iodide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

An ambient temperature solution of 3-(N,N-dimethylamino)-1-(3,4,5-trimethoxyphenyl)-propan-1-one (242.5 g, 0.91 mole) in Et2O (1.62 L) under nitrogen atmosphere was treated with methyl iodide (83 mL, 1.27 mole) and stirred for 2 hours. The resulting mixture was filtered and dried under high vacuum overnight at room temperature to provide 3-(N,N,N-trimethylammonio)-1-(3,4,5-trimethoxyphenyl)propan-1-one iodide as a white solid which was used without further purification.

Aufarbeitung

  1. filtrationThe resulting mixture was filtered
  2. customdried under high vacuum overnight at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-36f65644184048028aa490471da7b6af
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05010100

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