Benzylamine → N-benzyl-4,6-difluoropyrimidin-2-amine

HRID 1085889Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1085889
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[C:10]1[N:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[N:11]=1>C(OCC)C>[CH2:1]([NH:8][C:10]1[N:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[N:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 696772,4,6-Trifluoropyrimidine

Produkt 1

HCID 748218N-benzyl-4,6-difluoropyrimidin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

23.5 g (0.22 mol) of benzylamine were added at -20 C. to a stirred mixture of 13.4 9 (0.1 mol) of 2,4,6-trifluoropyrimidine in 150 ml of diethyl ether within 15 min, and the mixture was stirred at this temperature for 1 hour. After a further hour at 25° C., working up was carried out as in Example 10. 21.4 g (98% of theory) of the title compound of melting point 70°-73° C. were obtained in this way.

Aufarbeitung

  1. waitAfter a further hour at 25° C.

Quellen und Nachweise

ORD-Eintrag
ord-26e73770e712475dad75350abf1ead7b
Quelldatensatz
uspto-grants-1991_04
Patentnummer
US05011927

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