Acetic Acid → 4-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

HRID 1086236

Reaktionsgleichung

Reaktionsgleichung von HRID 1086236
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:30]=[CH:29][C:17]([CH:18]=[CH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)=[CH:16][CH:15]=1)=[O:13].C(O)(=[O:33])C.OO>ClCCl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][S:12]([C:14]1[CH:15]=[CH:16][C:17]([CH:18]=[CH:19][C:20]2[CH:21]=[CH:22][C:23]([C:24]([OH:26])=[O:25])=[CH:27][CH:28]=2)=[CH:29][CH:30]=1)(=[O:33])=[O:13]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 545127564-(4-(2-Quinolinylmethylsulfinyl)styryl)benzoic acid

Produkt 1

HCID 544571334-(4-(2-Quinolinylmethylsulfonyl)styryl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To 3 mmol of the sulfinyl compound from Step A in acetic acid (40 mmol) is added 30% hydrogen peroxide (2 ml). The mixture is stirred at ambient temperature and assayed by TLC. Upon disappearance of the sulfinyl starting compound, the reaction mixture is diluted with dichloromethane, washed with dilute aqueous sodium bisulfite and water, dried and evaporated to give 4-(4-(2-quinolinylmethylsulfonyl)-styryl)benzoic acid.

Aufarbeitung

  1. washwashed with dilute aqueous sodium bisulfite and water
  2. customdried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ba713437fb944dfcb0ab6e36deade4ae
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05028615

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