Boc-Gly-Gly-Val-Pro-OBzl → Boc-Gly-Gly-Val-Pro-OH
Reaktionsgleichung
[NH:1]([C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:30][CH2:29][CH2:28][C@H:17]1[C:18]([O:20]CC1C=CC=CC=1)=[O:19])=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[O:4]>C(O)(=O)C>[NH:1]([C:31]([O:33][C:34]([CH3:36])([CH3:35])[CH3:37])=[O:32])[CH2:2][C:3]([NH:5][CH2:6][C:7]([NH:9][C@H:10]([C:14]([N:16]1[CH2:30][CH2:29][CH2:28][C@H:17]1[C:18]([OH:20])=[O:19])=[O:15])[CH:11]([CH3:13])[CH3:12])=[O:8])=[O:4]Komponenten
3
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
IV (6.2 g, 0.012 mole) in acetic acid was hydrogenated and worked up as for IIto obtain V quantitatively, no sharp m.p. 74°-83° C. Rf3, 0.25; Rf4, 0.15. Anal. Calcd. for C19H32N4O7 : C, 51.10: H, 7.67; N, 12.54%. Found: C, 51.28: H, 7.50 N, 12.38%.
Aufarbeitung
- customobtain V quantitatively