Acetic Anhydride → N-(3-Chlorophenyl)acetamide
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[C:9]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)(=[O:11])[CH3:10]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 90 °C
Versuchsvorschrift
To 3-chloroaniline (10 g, 0.078 mol) was added portionwise acetic anhydride (32 g, 0.314 mol) in such a manner as to keep the temperature of the reaction mixture below 85° C. The reaction mixture was then stirred at 90° C. for 4 hours and then cooled to room temperature. The reaction mixture was then poured carefully into ice water, extracted with ethyl acetate and dried over sodium sulfate. The solvent was removed, yielding 30 g of N-acetyl-3-chloroaniline.
Aufarbeitung
- customthe temperature of the reaction mixture below 85° C
- temperaturecooled to room temperature
- extractionextracted with ethyl acetate
- dry with materialdried over sodium sulfate
- customThe solvent was removed
Quellen und Nachweise
- ORD-Eintrag
- ord-c22f2be1bb7d4cd7a687f81dea07ae3a
- Quelldatensatz
- uspto-grants-1991_07
- Patentnummer
- US05034410
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