p-Chlorothiophenol → 3'-(4-Chlorophenylthio)-4'-nitroacetophenone

HRID 1087185Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1087185
Cl[C:2]1[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([SH:21])=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1.O>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([S:21][C:2]2[CH:3]=[C:4]([C:11](=[O:13])[CH3:12])[CH:5]=[CH:6][C:7]=2[N+:8]([O-:10])=[O:9])=[CH:17][CH:16]=1

Komponenten

7

Edukt 4

HCID 7815p-ChlorothiophenolHCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 104427551-(3-Chloro-4-nitrophenyl)ethanone

Produkt 1

HCID 103805263'-(4-Chlorophenylthio)-4'-nitroacetophenoneAusbeute 82,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 3'-chloro-4'-nitroacetophenone (1.5 g), 4-chlorothiophenol (1.63 g) and potassium carbonate (1.56 g) in toluene (15 ml) was stirred at 70° C. for 5 hours. Ethyl acetate and water were added, and the organic layer was separated, washed with water, dried and evaporated to dryness. The residue was washed with toluene to give yellow crystals of 3'-(4-chlorophenylthio)-4'-nitroacetophenone (1.9 g).

Aufarbeitung

  1. customthe organic layer was separated
  2. washwashed with water
  3. customdried
  4. customevaporated to dryness
  5. washThe residue was washed with toluene

Quellen und Nachweise

ORD-Eintrag
ord-498c9783497a48b38347c9b20a02403c
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05034417

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