Sodium Hydroxide → Minoxidil

HRID 1087882

Reaktionsgleichung

Reaktionsgleichung von HRID 1087882
C([NH:4][C:5]1[N:10]([OH:11])[C:9](=[NH:12])[N:8]=[C:7]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=1)(=O)C.[OH-].[Na+]>C(O)C>[NH2:4][C:5]1[N:10]([OH:11])[C:9](=[NH:12])[N:8]=[C:7]([N:13]2[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[CH:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 140353008HCID 140353008, Verbindung

Produkt 1

HCID 4201Minoxidil

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

0 5 g (2 mmoles) of 6-acetamido-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine prepared as described in Example 6 is dissolved in a mixture containing 10 ml of ethanol and 4 ml of 1N sodium hydroxide solution, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. After taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give the aimed compound in a yield of 0.35 g (85%), which shows no melting point depression when mixed with the product of Example 1.

Aufarbeitung

  1. dissolutionis dissolved in a mixture
  2. temperaturethe mixture is refluxed for 30 minutes
  3. customevaporated under reduced pressure
  4. filtrationthe crystals are filtered
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-8e86641f6b2c4d86a1e65c727d246f00
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04960888

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