Minoxidil

HCID 4201CAS 38304-91-5

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Grundinformationen

Standard-SMILES: N=c1nc(N2CCCCC2)cc(N)n1O
InChIKey: ZIMGGGWCDYVHOY-UHFFFAOYSA-N
Summenformel: C9H15N5O
Durchschnittliche Molmasse: 209,25 g/mol
Monoisotopische Masse: 209,12766012

Namen und Bezeichner

Bevorzugter Name: Minoxidil
IUPAC: 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine
Lokaler Name: Minoxidil
Englischer Name: Minoxidil
Summenformel: C9H15N5O
Molmasse: 209.25

Namen und Synonyme

minoxidil38304-91-5RogaineLonitenMinoximenTheroxidilAlopexilAlostilRegaineTricoxidilLonoloxNormoxidil

Weitere Namen anzeigen

Minoxidil Basepdp2,4-diamino-6-piperidinopyrimidine3-n-oxideminoxidiMinoxidil powder4-pyrimidinediamine,6-(1-piperidinyl)-3-oxideMONOXIDILMinoxidil CRS4-pyrimidinediamine

PrexidilMinodylPierminox2,6-Diamino-4-(piperidin-1-yl)pyrimidine 1-oxideRiUP3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amineMintopU-10858

Datenbank-Bezeichner

CAS: 38304-91-5
PubChem CID: 4201
DTXSID: DTXSID301372970
ChEMBL: CHEMBL1372483、CHEMBL609587
ChEBI: CHEBI:6942
UNII: 5965120SH1
Nikkaji: J19.522G

Eigenschaften

Berechnete Struktureigenschaften

XLogP: 1,2
Polarare Oberfläche (TPSA): 88,9 Å²
H-Brücken-Donoren: 3
H-Brücken-Akzeptoren: 3
Frei drehbare Bindungen: 1
Schwere Atome: 15
Formalladung: 0
Komplexität: 329

Physikochemische Eigenschaften

Schmelzpunkt: 272 · 272-274 °C (dec.) (lit.)
Siedepunkt: 348.61 °C · 348.61°C (rough estimate)
Dichte: 1.1651 · 1.1651 (rough estimate)
Brechungsindex: 1.761 · 1.7610 (estimate)
storage temp.: 2 · 2-8°C
Löslichkeit: Slightly soluble in water, soluble in methanol and in propylene glycol.
pka: 4.61 · 4.61(at 25℃)
Aggregatzustand: Solid
Farbe: White
Wasserlöslichkeit: Soluble in water (2.2 mg/ml), 100% ethanol (29 mg/ml), propylene glycol, acetone, DMSO (6.5 mg/ml), and methanol.
Merck: 14 · 14,6203
BCS Class: 3 · 3
Stabilität: 2 years · Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Kosmetik-Inhaltsstoffe Funktionen: HAIR FIXINGHAIR CONDITIONING
InChI: 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChIKey: ZFMITUMMTDLWHR-UHFFFAOYSA-N
SMILES: NC1=CC(=NC(=N)N1O)N2CCCCC2
CAS Datenbank: 38304 · 38304-91-5(CAS DataBase Reference)
NIST chemische Informationen: Minoxidil(38304-91-5)

Sicherheit und Regulatorisches

Sicherheitsdaten

wgk: 3
hs_code: 29335990
RTECS-Nr.: UV8200000
risk_code: 22-36/37/38-26/27/28
Toxizität: LD50 in rats, mice (mg/kg): 49, 51 i.v. (Carlson, Feenstra)
hazard_code: Xn,T+
safety_code: 26-36-45-36/37/39-22
Speicherklasse: 11 - Combustible Solids
Giftige Stoffe Daten: 38304-91-5(Hazardous Substances Data)
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3

Chemie und Industrie

Anwendungen · 2 Einträge

BeschreibungMinoxidil is a peripheral vasodilator that directly relaxes vascular smooth musculature, thus, lowering systolic and diastolic pressure. Its action is linked to the activation of calcium channels. Open calcium channels cause hyperpolarization of smooth muscle cells, which in turn, reduces the flow of calcium ions into the cell, which is necessary for supporting vascular tonicity. However, when taking minoxidil, tachycardia, elevated renin secretion, and water and sodium ion retention all appear simultaneously with hypotension.

VerwendenUsed as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels

Vor- und nachgelagerte Produkte

Vorgelagerte Rohstoffe

Anbieter50 Anbieter

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

INTATRADE GmbH+49 3493/605464 · [email protected]

Ergänzende Hinweise · 1 Eintrag

DefinitionChEBI: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a pyrimidine N-oxide, a member of piperidines and an aminopyrimidine.