Phosphorus pentachloride → (2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl chloride;hydrochloride

HRID 1088247

Reaktionsgleichung

Reaktionsgleichung von HRID 1088247
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[NH2:7][C:8]1[S:12][N:11]=[C:10](/[C:13](=[N:17]/[O:18][CH3:19])/[C:14](O)=[O:15])[N:9]=1>C(Cl)Cl>[ClH:2].[NH2:7][C:8]1[S:12][N:11]=[C:10](/[C:13](=[N:17]/[O:18][CH3:19])/[C:14]([Cl:2])=[O:15])[N:9]=1

Komponenten

4

Edukt 2

HCID 24819Phosphorus pentachlorideHCID 101304122-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetic acid

Produkt 1

HCID 19930550(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetyl chloride;hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
-20 °C

Versuchsvorschrift

To a solution of 218 mg of phosphorus pentachloride in 3 ml of methylene chloride, 202 mg of 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetic acid is added under cooling at -20° C. with stirring and the mixture is stirred for half an hour at -20° C. and for two hours at -5° C. The reaction mixture in concentrated under reduced pressure and the residue is triturated with 10 ml of hexane. The precipitate is collected by filtration to give 2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z)-methoxyiminoacetyl chloride hydrochloride.

Aufarbeitung

  1. stirringthe mixture is stirred for half an hour at -20° C. and for two hours at -5° C
  2. concentrationThe reaction mixture in concentrated under reduced pressure
  3. customthe residue is triturated with 10 ml of hexane
  4. filtrationThe precipitate is collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-b725842e01dc4fee9d6796f94044609a
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04962100

Verknüpfte Notizen

Wird geladen…