Hydrochloric Acid → HCID 15671503, Verbindung

(2R,4R)-1-(p-Nitrobenzyloxycarbonyl)-2-(2,2-dimethoxycarbonylethyl)-4-t-butyldimethylsilyloxypyrrolidine (1.04 g) was dissolved in 6 ml of methanol, 3 ml of 4N sodium hydroxide solution was added thereto, and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was acidified with 6 ml of 6N hydrochloric acid, and 5 ml of tetrahydrofuran was added thereto. The resulting mixture was stirred at room temperature for 2 days, diluted with water, adjusted to alkaline with a saturated sodium bicarbonate solution and extracted with ether. The aqueous layer was acidified (pH 1) with dilute hydrochloric acid, extracted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate and distilled to obtain (2R,4R)-1-(p-nitrobenzyloxycarbonyl)-2-(2-carboxyethyl)-4-hydroxypyrrolidine.

1. additionwas added
2. stirringThe resulting mixture was stirred at room temperature for 2 days
3. extractionextracted with ether
4. extractionextracted with ethyl acetate
5. washwashed with water
6. dry with materialdried over anhydrous sodium sulfate
7. distillationdistilled

ORD-Eintrag

ord-d6e8ef938319424eb2401bfd10765d45

Quelldatensatz

uspto-grants-1990_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04962103