N-morpholinocarbonyl-L-phenylalanine benzyl ester → CP 84364

HRID 1088613

Reaktionsgleichung

Reaktionsgleichung von HRID 1088613
C([O:8][C:9](=[O:27])[C@H:10]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[NH:11][C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])C1C=CC=CC=1.[H][H]>CO.[Pd]>[O:17]1[CH2:18][CH2:19][N:14]([C:12]([NH:11][C@H:10]([C:9]([OH:27])=[O:8])[CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:13])[CH2:15][CH2:16]1

Komponenten

5

Edukt 2

HCID 14478228N-morpholinocarbonyl-L-phenylalanine benzyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 664657CP 84364Ausbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of N-morpholinocarbonyl-L-phenylalanine benzyl ester (1.43 g) in methanol (20 ml) was hydrogenated over 10% palladium on carbon (150 mg) at 3 atmospheric pressure of hydrogen for 1 hour. The solution was filtered and concentrated in vacuo to give N-morpholinocarbonyl-L-phenylalanine (1.02 g) as an amorphous powder.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-14ba90aef92248cb8d0b54e1cd080a1a
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04963530

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