Hydrochloric Acid → 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-(1,1-dimethylethyl)-6-fluoro-4-oxo-7-(1-piperazinyl)-

HRID 1089201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1089201
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([C:24]([CH3:27])([CH3:26])[CH3:25])[CH:7]=1)=[O:5])C.[OH-].[Na+].Cl>O>[N:18]1([C:11]2[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[C:24]([CH3:27])([CH3:25])[CH3:26])=[CH:13][C:12]=2[F:17])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14839606HCID 14839606, Verbindung

Produkt 1

HCID 4618761,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-(1,1-dimethylethyl)-6-fluoro-4-oxo-7-(1-piperazinyl)-Ausbeute 67,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

This ester 400 mg (1.06 mmoles) was suspended in 1 mL water, 1,9 mL 1N aqueous sodium hydroxide was added. The suspension was refluxed 30 minutes. The solution was cooled and adjusted to pH 7.5 with 1N hydrochloric acid. The precipitate was filtered and washed with water. The crude product was recrystallized in water to give 248 mg of titled compound. MP>270° C.

Aufarbeitung

  1. temperatureThe suspension was refluxed 30 minutes
  2. temperatureThe solution was cooled
  3. filtrationThe precipitate was filtered
  4. washwashed with water
  5. customThe crude product was recrystallized in water

Quellen und Nachweise

ORD-Eintrag
ord-58658bad6c8c4d4aacc1b39ba5f53069
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04965273

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