Dimethylformamide → HCID 14770848, Verbindung

HRID 1090386Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090386
[NH2:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([OH:13])=O)=[C:9]([F:17])[CH:8]=2)[CH2:3]1.[C:18](Cl)(=O)[C:19](Cl)=[O:20].CN(C)C=O.C(Cl)[Cl:30]>>[C:19]([NH:1][CH:2]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]([F:16])=[CH:14][C:10]([C:11]([Cl:30])=[O:13])=[C:9]([F:17])[CH:8]=2)[CH2:3]1)(=[O:20])[CH3:18]

Komponenten

5

Edukt 4

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 14770846HCID 14770846, Verbindung

Produkt 1

HCID 14770848HCID 14770848, Verbindung

Versuchsvorschrift

A mixture of 14.2 g (50 mmole) of 4-[3-(amino)cyclopentyl]-2,5-difluorobenzoic acid in 200 ml of methylene chloride was treated with 6.4 g (50 mmol) of oxalyl chloride and 0.5 ml of dimethylformamide. The reaction mixture was stirred at room temperature for 18 hours and the solvent removed in vacuo. The residue was triturated with toluene which was also removed in vacuo. The residue was used without further purification.

Aufarbeitung

  1. customthe solvent removed in vacuo
  2. customThe residue was triturated with toluene which
  3. customwas also removed in vacuo
  4. customThe residue was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-dd4b949499bf44c39c272230d216bb67
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05081254

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