HCID 601959, Verbindung → 3-(Trimethylsilyl)aniline

HRID 1090418Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090418
[N+:1]([C:4]1[CH:5]=[C:6]([Si:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-])=O>C1C=CC=CC=1.[Pd]>[CH3:11][Si:10]([CH3:13])([CH3:12])[C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[NH2:1]

Komponenten

4

Edukt 1

HCID 601959HCID 601959, Verbindung

Produkt 1

HCID 124888833-(Trimethylsilyl)anilineAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 241BenzeneLösungsmittel

Versuchsvorschrift

m-Nitrotrimethylsilylbenzene (200 mg) was catalytically hydrogenated over Pd-C in 7.5 ml of benzene at atmospheric pressure for 40 minutes. The catalyst was filtered off and washed with benzene and dry MeOH, successively. The filtrate and washings were mixed and evaporated. The residue was purified by column chromatography on silica gel [eluent: methylene chloride] to give 169 mg of pale brown liquid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with benzene and dry MeOH
  3. additionThe filtrate and washings were mixed
  4. customevaporated
  5. customThe residue was purified by column chromatography on silica gel [eluent: methylene chloride]

Quellen und Nachweise

ORD-Eintrag
ord-ab4926736b4a4afe870c4d8e79b7ac00
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05081271

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