2-Methyl-3-nitrobenzyl alcohol → (3-Amino-2-methylphenyl)methanol

HRID 1090633

Reaktionsgleichung

Reaktionsgleichung von HRID 1090633
[CH3:1][C:2]1[C:9]([N+:10]([O-])=O)=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(O)C.[Pd]>[NH2:10][C:9]1[C:2]([CH3:1])=[C:3]([CH:6]=[CH:7][CH:8]=1)[CH2:4][OH:5]

Komponenten

4

Edukt 1

HCID 902892-Methyl-3-nitrobenzyl alcohol

Produkt 1

HCID 577175(3-Amino-2-methylphenyl)methanolAusbeute 101,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 2-methyl-3-nitrobenzyl alcohol (2.0 g, 12 mmol) in ethanol (100 ml) was hydrogenated over 10% palladium/charcoal (0.1 g) for 2 hours, at an initial pressure of 3.5 bar. The solution was filtered through celite and evaporated to give 3-amino-2-methylbenzyl alcohol (1.67 g, quantitative), m.p. 104°-106°

Aufarbeitung

  1. filtrationThe solution was filtered through celite
  2. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-964ca6295eb64af1ac47407e4136b9c0
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05082848

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