Morpholine → HCID 19913646, Verbindung

HRID 1090664Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090664
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]1[CH2:26][O:25]1)(=[O:5])[CH2:2][CH2:3][CH3:4].[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>O1CCOCC1>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]([OH:25])[CH2:26][N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 99749123-Butyryl-4-(2-methylphenylamino)-8oxiranylquinoline

Produkt 1

HCID 19913646HCID 19913646, VerbindungAusbeute 47,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3-Butyryl-4-(2-methylphenylamino)-8-oxiranylquinoline (1.0 g, 2.89 mmol) and morpholine (1.0 g, 11.55 mmol) in dioxan (20 ml) were heated under reflux for 9 hours. The dioxan was evaporated and the residue dissolved in ethyl acetate, washed with brine, dried and evaporated to an oil which crystallised from ether. Recrystallisation from dichloromethane/ether gave 3-butyryl-4-(2-methylphenylamino)-8-(1-hydroxy-2-morpholinoethyl)quinoline (0.59 g, 47%), m.p. 135°-137°.

Aufarbeitung

  1. temperatureunder reflux for 9 hours
  2. customThe dioxan was evaporated
  3. dissolutionthe residue dissolved in ethyl acetate
  4. washwashed with brine
  5. customdried
  6. customevaporated to an oil which
  7. customcrystallised from ether
  8. customRecrystallisation from dichloromethane/ether

Quellen und Nachweise

ORD-Eintrag
ord-36092fa0cd0b4b538eba1e2c7baa52c5
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05082841

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