Sodium Hydroxide → (2S)-2-(4-bromophenyl)oxirane
Reaktionsgleichung
[OH-].[Na+].Br[CH2:4][C@H:5]([C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[OH:6]>C(OCC)C>[Br:13][C:10]1[CH:11]=[CH:12][C:7]([C@H:5]2[CH2:4][O:6]2)=[CH:8][CH:9]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Aqueous sodium hydroxide (1M, 400 ml) was added to 2-bromo-(1S)-1-(4-bromophenyl)ethanol (77.0 g) in diethyl ether (400 ml) and stirred at room temperature for 5 hours. The organic layer was separated and aqueous layer was extracted with ether. The combined organic layer was washed with brine and dried over anhydrous sodium sulfate. Removal of the solvent yielded (2S)-2-(4-bromophenyl) oxirane (55.0 g) as a pale brown oil.
Aufarbeitung
- customThe organic layer was separated
- extractionaqueous layer was extracted with ether
- washThe combined organic layer was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customRemoval of the solvent
Quellen und Nachweise
- ORD-Eintrag
- ord-339c6f5186ae4c92b386345a07b37205
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08129377B2
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