Hydrochloric Acid → HCID 66593501, Verbindung

HRID 1091663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1091663
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][C:11]#[N:12].[H-].[Na+].Cl[C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1.Cl>C1COCC1.O>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[NH:3][C:2]1=[C:10]([C:16]1[N:21]=[CH:20][CH:19]=[CH:18][N:17]=1)[C:11]#[N:12]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 744042-ChloropyrimidineHCID 3424652-(1,3-Benzothiazol-2-yl)acetonitrile

Produkt 1

HCID 66593501HCID 66593501, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-(Benzothiazol-2-yl)acetonitrile (0.69 g, 4 mmol) was added in portions to a suspension of 95% sodium hydride ((0.21 g, 6 mmol) in THF (12 mL). The resulting yellow suspension was stirred at room temperature for 30 min, and 2-chloropyrimidine (0.45 g, 4 mmol) was added. The mixture was stirred for 3 d, and water was added to the dark solution. The mixture was acidified with 1N hydrochloric acid, and the precipitate that formed was collected by filtration, washed with water and acetonitrile, and dried under vacuum to give 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetonitrile as a brown solid.

Aufarbeitung

  1. stirringThe mixture was stirred for 3 d
  2. customthe precipitate that formed
  3. filtrationwas collected by filtration
  4. washwashed with water and acetonitrile
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-37ea5497767e4de7b014945facdd8c4a
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129396B2

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