Sodium Hydroxide → 1-(4-Bromothiophen-2-yl)-N-methylmethanamine
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.Cl.CN.[C:12]([BH3-])#[N:13].[Na+].[OH-].[Na+]>C(#N)C>[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][NH:13][CH3:12])[S:5][CH:6]=1Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
10.6 g of 4-bromothiophene-2-carbaldehyde are dissolved in 100 mL of acetonitrile, and 11.8 g of methylamine hydrochloride and 6.28 g of sodium cyanoborohydride are added. The reaction mixture is stirred overnight at room temperature. The reaction is stopped with 1 M sodium hydroxide solution. After evaporating off the solvents, the residue is chromatographed on silica gel (7/3 heptane/ethyl acetate). 8.19 g of (4-bromothiophen-2-ylmethyl)methylamine are obtained. Yield=79%.
Aufarbeitung
- customAfter evaporating off the solvents
- customthe residue is chromatographed on silica gel (7/3 heptane/ethyl acetate)
Quellen und Nachweise
- ORD-Eintrag
- ord-02c4de786aed4f4b9f1579f5f6c8fcd7
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08129416B2
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