Dimethylformamide → HCID 86633065, Verbindung

HRID 1094201Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1094201
CN(C=O)C.[CH:6]1([NH:12][C:13]2[CH:22]=[C:21]3[C:16]([C:17](=[O:35])[C:18]([NH:28][CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:19][N:20]3[CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[CH:15][C:14]=2[F:36])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[CH2:37](Br)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1.C(=O)([O-])[O-].[K+].[K+]>O>[CH2:37]([N:28]([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[C:18]1[C:17](=[O:35])[C:16]2[C:21](=[CH:22][C:13]([NH:12][CH:6]3[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]3)=[C:14]([F:36])[CH:15]=2)[N:20]([CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[CH:19]=1)[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1

Komponenten

6

Edukt 4

HCID 6228DimethylformamideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 86633053HCID 86633053, Verbindung

Produkt 1

HCID 86633065HCID 86633065, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a 3.2 ml DMF solution of 160 mg of ethyl {[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydro quinolin-3-yl]amino}acetate were added 0.05 ml of benzyl bromide and 75 mg of potassium carbonate, followed by overnight stirring at room temperature. By adding water to the reaction mixture and collecting the insoluble materials by filtration, 200 mg of ethyl {benzyl[7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-4-oxo-1,4-dihydro quinolin-3-yl]amino}acetate was obtained.

Aufarbeitung

  1. customcollecting the insoluble materials
  2. filtrationby filtration

Quellen und Nachweise

ORD-Eintrag
ord-501c38138fea4bfea941137a7a2db8a6
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08133882B2

Notizen zur Reaktion

Wird geladen…