5-(2-Methylpropyl)thiophene-2-carboxylic acid → 1-[5-(2-Methylpropyl)thiophen-2-yl]ethan-1-one
Reaktionsgleichung
[CH2:1]([C:5]1[S:9][C:8]([C:10]([OH:12])=O)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].[CH3:13][Li]>C(OCC)C>[CH2:1]([C:5]1[S:9][C:8]([C:10](=[O:12])[CH3:13])=[CH:7][CH:6]=1)[CH:2]([CH3:3])[CH3:4]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 5-isobutyl-thiophene-2-carboxylic acid (550 mg, 2.99 mmol) in diethyl ether (20 mL), a solution of methyl lithium (3.75 mL, 1.6 M in diethyl ether) is slowly added at rt. The reaction mixture is stirred at rt for 1 h before it is carefully washed twice with water, dried over MgSO4, filtered and evaporated to give the title compound (336 mg) as a slightly yellow oil, LC-MS: tR=0.91 min, [M+1]+=183.07.
Aufarbeitung
- washis carefully washed twice with water
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-9c5bd0bff067425388c3cf79153530a4
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08133910B2
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