Lithium hydroxide, monohydrate → 2-Aminoterephthalic acid

HRID 1094727

Reaktionsgleichung

Reaktionsgleichung von HRID 1094727
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([O:13]C)=[O:12])[C:5]([OH:7])=[O:6].O[Li].O>C1COCC1.CO.O>[NH2:1][C:2]1[CH:3]=[C:4]([C:5]([OH:7])=[O:6])[CH:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12]

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 52355003-Amino-4-(methoxycarbonyl)benzoic acid

Produkt 1

HCID 27248222-Aminoterephthalic acidAusbeute 63 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21892291Methanol tetrahydrofuran waterLösungsmittel

Versuchsvorschrift

3-Amino-4-(methoxylcarbonyl)benzoic acid (2.5 g, 12.8 mmol) was dissolved in a mixture of THF-MeOH—H2O (40 mL, 30:5:5) and then LiOH—H2O (2 g, 64 mmol) was added. The mixture stirred at RT over night. The reaction mixture was concentrated and the residue was dissolved in 5 mL of water and then acidified with 6N HCl to pH˜3. The solid was filtered and dried to give the desired product in 63% yield.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in 5 mL of water
  3. filtrationThe solid was filtered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-43aae2f408c444f995f05a7c7bc98939
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08133998B2

Verknüpfte Notizen

Wird geladen…