Tert-Butylamine → N-t-Butyl 3-bromobenzamide

HRID 1095065Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1095065
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH:15][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:6]

Komponenten

4

Edukt 2

HCID 6385Tert-ButylamineHCID 74377Benzoyl chloride, 3-bromo-

Produkt 1

HCID 603211N-t-Butyl 3-bromobenzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 3-bromo-benzoyl chloride (0.83 g, 3.8 mmol) in DCM (10 mL) was chilled to zero degrees and treated with tert-butylamine (1.2 mL, 11.3 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (0.9 g, 94%).

Aufarbeitung

  1. customReaction
  2. customto come to room temperature
  3. additionMixture was then poured onto water
  4. washwashed once
  5. washOrganic phase then washed with brine
  6. dry with materialdried over sodium sulfate
  7. filtrationfiltered
  8. customevaporated to amber oil (0.9 g, 94%)

Quellen und Nachweise

ORD-Eintrag
ord-d782f58911c5426093582a1a5e849716
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08133900B2

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