Sulfuric Acid → Methyl 2-acetamido-3-(cyclopropylmethoxy)-4-methoxybenzoate
Reaktionsgleichung
S(=O)(=O)(O)O.[NH2:6][C:7]1[C:16]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[C:15]([O:22][CH3:23])[CH:14]=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10].[C:24](OC(=O)C)(=[O:26])[CH3:25]>>[C:24]([NH:6][C:7]1[C:16]([O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[C:15]([O:22][CH3:23])[CH:14]=[CH:13][C:8]=1[C:9]([O:11][CH3:12])=[O:10])(=[O:26])[CH3:25]Komponenten
4
Reaktionsbedingungen
- Temperatur
- 30 °C
Versuchsvorschrift
Sulfuric acid (1 mL) was added dropwise to a solution of methyl 2-amino-3-(cyclopropylmethoxy)-4-methoxybenzoate (98%, 187 g, 0.73 mol) and acetic anhydride (372 g, 3.65 mol). The reaction was warmed at 30° C. overnight, quenched with water/ice (1.5 L), and then stirred vigorously for 30 min. The resulting solids were collected by filtration and dried in an oven to give 140 g of methyl 2-acetamido-3-(cyclopropylmethoxy)-4-methoxybenzoate as a white solid. MS (ESI): 293.9.