2-Methyl-3-(trifluoromethyl)benzyl alcohol → 2-Methyl-3-(trifluoromethyl)benzaldehyde

HRID 1096831Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1096831
[CH3:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

Komponenten

4

Edukt 1

HCID 27756102-Methyl-3-(trifluoromethyl)benzyl alcohol

Produkt 1

HCID 37191482-Methyl-3-(trifluoromethyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14801Manganese dioxideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a sol. of 2-methyl-3-trifluoromethylbenzyl alcohol (0.500 g, 2.63 mmol) in CH2Cl2 (25 mL) was added activated MnO2 (2.29 g, 26.3 mmol). After stirring for 72 h, the mixture was filtered over Celite, and the solvents were removed under reduced pressure. The aldehyde is used in the next step without further purification. 1H NMR (CDCl3) δ 10.40 (s, 1H), 8.00 (d, 1H), 7.85 (d, 1H), 7.45 (t, 1H), 2.8 (s, 3H).

Aufarbeitung

  1. filtrationthe mixture was filtered over Celite
  2. customthe solvents were removed under reduced pressure
  3. customThe aldehyde is used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-8d06c68ad251450f9c1b069ecc633508
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138340B2

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