tert-Butyl carbazate → 1,1-Dimethylethyl 2-[(2-chloro-4-fluorophenyl)acetyl]hydrazinecarboxylate

A solution of 2-chloro-4-fluorophenylacetyl chloride (10 mmol) in dry DCM (15 ml) was added over 20 min to a mixture of t-butyl carbazate (1.32 g, 10 mmol) and DIPEA (1.77 ml, 10.2 mmol) in dry DCM (20 ml). After stirring for a further 2 h, the mixture was washed with 1M HCl then with aqueous NaHCO3. A white solid precipitated at this point, which was filtered off, washed with water and DCM then dried to yield 1,1-dimethylethyl 2-[(2-chloro-4-fluorophenyl)acetyl]hydrazinecarboxylate (1.94 g).

1. washthe mixture was washed with 1M HCl
2. customA white solid precipitated at this point, which
3. filtrationwas filtered off
4. washwashed with water and DCM
5. customthen dried

ORD-Eintrag

ord-f73a78a286de418b8d486f62fa06453a

Quelldatensatz

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08143264B2