Sodium borohydride → HCID 59277703, Verbindung

HRID 1097775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1097775
[BH4-].[Na+].[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:18])=[O:17]>CCO>[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]([OH:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:17])=[O:18]

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 59277705HCID 59277705, Verbindung

Produkt 1

HCID 59277703HCID 59277703, VerbindungAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

NaBH4 (45 mg, 1.2 mmol) is added to a solution of 1,3,3-Trimethyl-2,2-dioxo-2,3-dihydro-1H-benzo[c][1,2]thiazin-4-one (190 mg, 0.8 mmol) in 15 mL of EtOH at 0° C. The resulting mixture is stirred at this temperature for overnight. The reaction is quenched by HCl (1M), and extracted with ethyl acetate (15 mL×3). The combined extracts are dried over anhydrous Na2SO4. After filtration and concentration, the residue is purified by flash column and yields the title compound as oil (193 mg).

Aufarbeitung

  1. customThe reaction is quenched by HCl (1M)
  2. extractionextracted with ethyl acetate (15 mL×3)
  3. dry with materialThe combined extracts are dried over anhydrous Na2SO4
  4. filtrationAfter filtration and concentration
  5. customthe residue is purified by flash column

Quellen und Nachweise

ORD-Eintrag
ord-20043f9432974a28b0460af2f9fb8491
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143278B2

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