Ammonia → 4-Bromo-2-chlorobenzenesulfonamide

To a solution of 4-bromo-2-chlorobenzenesulfonyl chloride (2.50 g, 8.45 mmol) in THF (25 ml) was added a solution of ammonia (25%, 6.3 ml, 84.5 mmol). The reaction mixture was stirred for 4 h at RT. Ethyl acetate (70 ml) and water (50 mL) were added. The organic phase was separated and washed with hydrochloric acid (1 M, 50 ml) and brine (2×30 ml) and dried over sodium sulfate. After evaporation the product was obtained as a white solid (2.05 g, 90%) which was used in the next step without further purification.

1. customThe organic phase was separated
2. washwashed with hydrochloric acid (1 M, 50 ml) and brine (2×30 ml)
3. dry with materialdried over sodium sulfate
4. customAfter evaporation the product

ORD-Eintrag

ord-f8ce2044d6b6470ba4d1e404f4dfdf2e

Quelldatensatz

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08143242B2