Acetic Anhydride → 1,1-Cyclohexanediacetic Anhydride

HRID 1099480

Reaktionsgleichung

Reaktionsgleichung von HRID 1099480
[C:1]1([CH2:11][C:12]([OH:14])=[O:13])([CH2:7][C:8]([OH:10])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(OC(=O)C)(=O)C>>[C:1]12([CH2:7][C:8](=[O:10])[O:14][C:12](=[O:13])[CH2:11]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 78061Cyclohexanediacetic acid

Produkt 1

HCID 27342891,1-Cyclohexanediacetic AnhydrideAusbeute 100 %

Versuchsvorschrift

A suspension of 1,1-cyclohexanediacetic acid (39.95 mmol) in acetic anhydride (159.8 mmol) was refluxed gently until a clear solution was obtained (ca. 1 h). The reaction mixture was kept at reflux for another hour until the reaction was complete. The reaction mixture was cooled to room temperature and acetic acid and excess acetic anhydride were removed under vacuum to afford 7.28 g (100%) of (3). 1H NMR (CDCl3): 2.65 (4H, s); 1.54-1.43 (10H, m).

Aufarbeitung

  1. temperaturewas refluxed gently until a clear solution
  2. customwas obtained (ca. 1 h)
  3. temperatureat reflux for another hour until the reaction
  4. customacetic acid and excess acetic anhydride were removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-51de30396c24492eb2e411b3fe2b9630
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143437B2

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