Methoxycarbonyl isothiocyanate → HCID 54270269, Verbindung

HRID 1105840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1105840
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6].[C:21]([N:25]=[C:26]=[S:27])([O:23][CH3:24])=[O:22]>C(OCC)C>[C:21]([NH:25][C:26](=[S:27])[NH:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:6])([O:23][CH3:24])=[O:22]

Komponenten

4

Edukt 2

HCID 552246Methoxycarbonyl isothiocyanateHCID 54315355HCID 54315355, Verbindung

Produkt 1

HCID 54270269HCID 54270269, VerbindungAusbeute 10,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 3-amino-4-n-butylaminobenzophenone (2.38 g.) in diethyl ether (200 ml.) is added carbomethoxy isothiocyanate (1.4 g.). The reaction mixture is stirred at room temperature for three hours. The product is collected by filtration and dried to afford 0.2 g. of product, m.p. 160°-162° C., dec. The filtrate is allowed to stand overnight at room temperature and a second crop is collected amounting to 0.15 g., m.p. 162° C., dec. The total amount of 3-(3-carbomethoxythioureido)-4-n-butylaminobenzophenone obtained is 0.35 g. (10.2% yield).

Aufarbeitung

  1. filtrationThe product is collected by filtration
  2. customdried
  3. customto afford 0.2 g
  4. waitto stand overnight at room temperature
  5. customa second crop is collected amounting to 0.15 g

Quellen und Nachweise

ORD-Eintrag
ord-776f5aaee6834c3b9e4d24dcc73faa33
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04310537

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