Tert-Butylamine → 1-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol

HRID 1106094Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1106094
[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:3][CH2:2]1.[C:20]([NH2:24])([CH3:23])([CH3:22])[CH3:21]>>[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][O:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][NH:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:11][CH:10]=2)[CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 6385Tert-ButylamineHCID 150353032-((4-(2-(Cyclopropylmethoxy)ethoxy)phenoxy)methyl)oxirane

Produkt 1

HCID 30474911-{4-[2-(Cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-olAusbeute 74 %

Versuchsvorschrift

Following the procedure of Example I, 1-{4-[2-(cyclopropylmethoxy)-ethoxy]-phenoxy}-2,3-epoxy-propane is prepared and then treated with t-butylamine. 7.6 g (yield=74%) of crude 1-{4-[2-(cyclopropylmethoxy)-ethoxy]phenoxy}-3-t-butylamino-propan-2-ol are thus obtained, and this material is converted to the fumarate by mixing stoichiometric amounts of the base and of the acid in solution in isopropanol. The neutral fumarate which has precipitated is filtered off and recrystallised from ethanol (yield=80%), M.p.=158°-160° C.

Aufarbeitung

  1. customis prepared

Quellen und Nachweise

ORD-Eintrag
ord-1eb85eb6b09342ea8ccc7035332251d7
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04311708

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