Isobutyraldehyde → 3-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

HRID 1106128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1106128
[CH:1](=[O:5])[CH:2]([CH3:4])[CH3:3].[CH2:6]([NH:8][CH2:9][CH2:10]O)[CH3:7]>C1C=CC=CC=1>[CH:2]([CH:1]1[N:8]([CH2:9][CH3:10])[CH2:6][CH2:7][O:5]1)([CH3:4])[CH3:3]

Komponenten

4

Edukt 2

HCID 6561IsobutyraldehydeHCID 80722-(Ethylamino)ethanol

Produkt 1

HCID 2588383-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Iso-butyraldehyde (11.1 g; 0.15 moles) was added slowly over a period of 1 hour to N-ethyl-2-hydroxyethylamine (13.3 g; 0.15 moles) at a temperature of 25°-30° C. Benzene (100 ml) was then added, and the resulting solution was heated to reflux. Continuous azeotropic distillation removed 2.8 ml of water. The benzene was then removed by vacuum distillation to give the desired 2-isopropyl-3-ethyl-1,3-oxazolidine as a yellow liquid.

Aufarbeitung

  1. temperaturethe resulting solution was heated to reflux
  2. distillationContinuous azeotropic distillation
  3. customremoved 2.8 ml of water
  4. customThe benzene was then removed by vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-9b4f380f3806411aab25c8692a8df7e9
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04311827

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